Protein Secondary Structure Prediction and Perceptions of Complexities using Deep Neural Network

Abstract

The Protein molecule is known as the large biological molecule in a living organism. The protein performs several works like transporting molecules, catalysing metabolic reaction, responding to stimuli etc in a human body. Protein Structure analysis and prediction is very much essential to make any research about the same protein molecule. The basic intention of protein structure prediction (PSP) is to predict the three dimensional structure that generate by the amino acid sequence. The very peculiar matter is only twenty amino acid found in a living body where as approximately one lakh protein molecules can be framed from the same amino acid compositions in different percentages.  The three dimensional structure framed by the amino acid compositions generally changes its shape and size due to the effect of external agents or medicines that comes in contact with these protein molecules. The basic intention behind the prediction of structure of the protein is to design new drugs or medicines. From the structures the medicine researchers working for the development of medicines may easily detect the changes in the living body or the requirement of drugs or medicines. The detection of the structure and the prediction of perfect structure is always a challenging task. The protein structure is basically a three dimensional structure in its secondary transformation. The structure may be in the form of ? Helix, ? sheets or loop etc. In this paper the identification of the secondary structures and the percentages of ? Helix, ? sheets or loop structures are being predicted and the probable complexities that may occur during the prediction is discussed. Deep neural network is a deep structured learning process is an application of the broader family machine learning. Deep learning architectures has a number application in various fields like medical science, bioinformatics, medical image analysis etc. A novel method is being proposed in this research article for the detection, correction and removal of various complexities during prediction using deep neural network. This technique will be helpful for different researchers working in the field for drug design and medicine research.