Computational based Structural, Functional and Phylogenetic Analyses Of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate (DAHP) Synthase of Corynebacterium Spp

Abstract

The pathway of aromatic amino acid biosynthesis was initiated by the enzyme DAHP synthase. In this branched biosynthetic pathway phenylalanine, tyrosine and tryptophan are produced. This enzyme was repressed and inhibited by three said end product of aromatic amino acids. The importance of this enzyme is microbial fermentation of aromatic amino acid production. The present study envisaged the in silico analysis of this protein (DAHP synthase). The structural, functional and phylogenetic studies of this protein of Corynebacteriumglutamicum have been determined and it was observed that the protein of interest is a thermostable, acidic protein having molecular weight ranging in between 38.67 to 52.32 kDa.