A Study on Cyclosporine a Production by Fungal Cells

Abstract

Cyclosporin A (CyA) is found as an antibiotics, exhibiting immunosuppressive and antifungal properties. Cyclosporine A has been synthesized in large quantities by fermentation process using various fungal species such as Tolypocladium, Trichoderma, Fusarium Penicillium and Aspergillus spp. Submerged liquid fermentation (SLF) and solid state fermentation (SSF) have been used successfully to produce the Cyclosporin A. The SSF is alternative to submerged fermentation for production of value added products like antibiotics. In solid-state fermentation (SSF), growth of microbes is occurred without free flowing aqueous phase. It provides low availability of water and reduces the possibilities of contamination by bacteria and yeast. SSF can provide higher yields and other advantages for this product. Due to the concentrated nature of the substrate, smaller reactors could be used in SSF. An industrial point of view, it is necessity to obtain a suitable and economic medium and process for higher production of CyA. CyA is produced by using Tolypocladium inflatum in solid state fermentation.